منابع مشابه
Genome Sequences from Extinct Relatives
Next-generation sequencing methods use massively parallel detection of short sequencing reactions, making them ideal for the analysis of ancient DNA. In this issue, Green et al. (2008) exploit this feature to infer the complete mitochondrial genome sequence of one Neanderthal and place bounds on its time of common ancestry with modern humans.
متن کاملReproducibility of ancient DNA sequences from extinct Pleistocene fauna.
The study of DNA sequence data obtained from specimens of extinct organisms offers a window into the evolutionary past. However, this area of research is technically very challenging and is strewn with potential pitfalls. Handt et al. (1994) and others (Lindahl 1993; Paabo, Higuchi, and Wilson 1989) have emphasised the need for careful experimental design and procedure in ancient DNA work as we...
متن کاملResurrection of DNA Function In Vivo from an Extinct Genome
There is a burgeoning repository of information available from ancient DNA that can be used to understand how genomes have evolved and to determine the genetic features that defined a particular species. To assess the functional consequences of changes to a genome, a variety of methods are needed to examine extinct DNA function. We isolated a transcriptional enhancer element from the genome of ...
متن کاملCompiling Multicopy Single-Stranded DNA Sequences from Bacterial Genome Sequences.
A retron is a bacterial retroelement that encodes an RNA gene and a reverse transcriptase (RT). The former, once transcribed, works as a template primer for reverse transcription by the latter. The resulting DNA is covalently linked to the upstream part of the RNA; this chimera is called multicopy single-stranded DNA (msDNA), which is extrachromosomal DNA found in many bacterial species. Based ...
متن کاملDNA sequences from the adenovirus 2 genome.
The sequence of 5,839 nucleotides from the adenovirus 2 genome has been determined and includes the regions between coordinates 32-44% and 66-71%. These regions contain the coding sequences for the 52,55K polypeptide, polypeptide IIIa, penton base, and the N terminus of the 100K polypeptide. Several additional unidentified open reading frames are present, including examples which overlap identi...
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ژورنال
عنوان ژورنال: Cell
سال: 2008
ISSN: 0092-8674
DOI: 10.1016/j.cell.2008.07.026