Genome profiling of ERBB2-amplified breast cancers
نویسندگان
چکیده
منابع مشابه
Prognosis and gene expression profiling of 20q13-amplified breast cancers.
PURPOSE Amplification of chromosomal region 20q13 occurs in breast cancer but remains poorly characterized. EXPERIMENTAL DESIGN To establish the frequency of 20q13 amplification and select the amplified cases to be studied, we used fluorescence in situ hybridization of bacterial artificial chromosome probes for three 20q13 loci (MYBL2, STK6, ZNF217) on sections of tissue microarrays containin...
متن کاملGenetic alterations in ERBB2-amplified breast carcinomas.
Amplification of the ERBB2 oncogene has recently received attention as a target for antibody-based therapies and as a predictor of response to adjuvant chemotherapy. Modification of treatment strategies based on ERBB2 status has led to further interest in the genetic alterations that accompany ERBB2 gene amplification or overexpression. In this study, chromosome alterations that are associated ...
متن کاملRegulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers.
In breast cancer, overexpression of ErbB2 or aberrant regulation of survivin, a member of the inhibitor of apoptosis family, is associated with resistance to chemo/hormone therapy and predicts for a poor clinical outcome. A functional link between the two predictive factors has not been previously shown. Here, using genetic and pharmacologic approaches to block ErbB2 signaling, we show that Erb...
متن کاملALK gene amplified in most inflammatory breast cancers.
I nflammatory breast cancer (IBC) is a rare form of the disease that differs substantially from noninflammatory breast cancer in presentation and response to therapy. Despite those differences, researchers have uncovered few molecular characteristics that distinguish IBC from noninflammatory breast cancer, and IBC treatment generally relies on standard breast cancer regimens. Cancer Center in H...
متن کاملMYC is amplified in BRCA1-associated breast cancers.
PURPOSE Germ-line mutations in the BRCA1 tumor suppressor gene predispose to early onset breast cancers with a distinct phenotype characterized by high tumor grade, aneuploidy, high proliferation rate, and estrogen receptor-negativity. The molecular mechanisms and cooperative oncogenes contributing to multistep tumor progression in cells lacking BRCA1 are not well defined. To examine whether C-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Cancer
سال: 2010
ISSN: 1471-2407
DOI: 10.1186/1471-2407-10-539