Genome Editing for Sickle Cell Disease: A Little BCL11A Goes a Long Way
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A little Cdc20 goes a long way
A little Cdc20 goes a long way C dc20 drives mitotic cells from metaphase into anaphase. Once metaphase chromosomes are aligned at the center of the mitotic spindle, Cdc20 activates the E3 ubiquitin ligase APC/C to trigger the degradation of cyclin B1 and securin, allowing sister chromatids to separate and move toward opposite poles (1). Cdc20 is so essential for mitotic progression that mouse ...
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1. Hamilton, W.D. (1964). The genetical evolution of social behaviour I & II. J. Theor. Biol. 7, 1–16 and 17–52. 2. Hain, T.J.A., and Neff, B.D. (2006). Promiscuity drives self-referent kin recognition. Curr. Biol. 16, 1807–1811. 3. Sherman, P.W., Reeve, H.K., and Pfennig, D.W. (1997). Recognition systems. In Behavioural Ecology, Fourth edition, J.R. Krebs and N.B. Davies, eds. (Malden, MA: Bla...
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In this issue of the Proceedings, Starovasnik, Braisted, and Wells (1) present the solution structure of synthetic peptides that are half the size of their natural counterpart, but nonetheless maintain well ordered structures and bind tightly to their natural target site. Small protein domains that are structurally stable and functionally active serve as attractive models for studies of protein...
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Hyponatremia is common in hospitalized patients. By taking a careful and logical approach, one can promptly recognize the causative factor or factors in nearly all cases. Most cases of hyponatremia are due to impaired renal water excretion, and recognizing the cause and pathophysiologic process makes it possible to provide focused individualized care and avoid mistreatment.
متن کاملMicrotubule Mechanics: A Little Flexibility Goes a Long Way
Microtubules are the least flexible of the cytoskeletal filaments, yet they are occasionally seen to be severely buckled in cells. A recent analysis suggests these buckles are evidence of high contractile forces throughout the cytoplasm, and that the other elements of the cytoskeleton laterally reinforce microtubules to help prevent their collapse.
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2017
ISSN: 1525-0016
DOI: 10.1016/j.ymthe.2017.02.003