Genome Architecture and Its Roles in Human Copy Number Variation
نویسندگان
چکیده
منابع مشابه
Genome Architecture and Its Roles in Human Copy Number Variation
Besides single-nucleotide variants in the human genome, large-scale genomic variants, such as copy number variations (CNVs), are being increasingly discovered as a genetic source of human diversity and the pathogenic factors of diseases. Recent experimental findings have shed light on the links between different genome architectures and CNV mutagenesis. In this review, we summarize various geno...
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DNA copy number variation (CNV) was recently discovered as a significant part of human genetic variation. This variation affects genes as well as intergenic regions. Herein, current insight into the effects of CNV on gene expression is summarized. The consequences of intergenic CNVs are poorly understood. For CNV affecting genes, a dosage compensation mechanism seems to be applied on a subset o...
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ژورنال
عنوان ژورنال: Genomics & Informatics
سال: 2014
ISSN: 2234-0742
DOI: 10.5808/gi.2014.12.4.136