Genetics of anterior segment dysgenesis disorders
نویسندگان
چکیده
منابع مشابه
Anterior segment dysgenesis in mosaic Turner syndrome.
AIMS/BACKGROUND Females with Turner syndrome commonly exhibit ophthalmological abnormalities, although there is little information in the literature documenting findings specific to Turner syndrome mosaics. Ophthalmic findings are described in four patients with mosaic Turner syndrome. All had anterior chamber abnormalities and all four had karyotypic abnormalities with a 45, X cell line. The p...
متن کاملAnterior segment dysgenesis in a child with factor VII deficiency
PURPOSE To describe the first case of anterior segment dysgenesis associated with factor VII congenital deficit (hypoproconvertinemia). METHOD A 2-month-old child with factor VII deficiency was referred to our clinic because of corneal opacities. The child was born to consanguineous parents and severe factor VII deficiency was diagnosed on the third day of life because of gastrointestinal ble...
متن کاملAnterior segment dysgenesis and the developmental glaucomas are complex traits.
Glaucoma refers to a heterogeneous group of disorders that involve retinal ganglion cell death, optic nerve damage, and loss of visual field. Glaucoma is a leading cause of vision loss worldwide, affecting an estimated 67 million people. Elevated intraocular pressure is a major risk factor for glaucoma. Individuals with malformations of structures of the anterior segment of the eye frequently d...
متن کاملFormation of corneal endothelium is essential for anterior segment development - a transgenic mouse model of anterior segment dysgenesis.
The anterior segment of the vertebrate eye is constructed by proper spatial development of cells derived from the surface ectoderm, which become corneal epithelium and lens, neuroectoderm (posterior iris and ciliary body) and cranial neural crest (corneal stroma, corneal endothelium and anterior iris). Although coordinated interactions between these different cell types are presumed to be essen...
متن کاملTopical tacrolimus in anterior segment inflammatory disorders
Immune mediated inflammatory anterior segment diseases are variable and their management requires intense immunosuppression. Treatment with topical steroids is associated with serious ocular side effects. In order to overcome the potentially blinding complications of topical steroids, immunomodulatory drugs are being used more frequently. Tacrolimus is a calcineurin inhibitor that induces suppr...
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ژورنال
عنوان ژورنال: Current Opinion in Ophthalmology
سال: 2011
ISSN: 1040-8738
DOI: 10.1097/icu.0b013e328349412b