Genetics and Epigenetics of Recurrent Hydatidiform Moles: Basic Science and Genetic Counselling
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چکیده
منابع مشابه
Genetics and Epigenetics of Recurrent Hydatidiform Moles: Basic Science and Genetic Counselling
Gestational trophoblastic disease (GTD) is a group of conditions that originate from the abnormal hyperproliferation of trophoblastic cells, which derive from the trophectoderm, the outer layer of the blastocyst that would normally develop into the placenta during pregnancy. GTDs encompass hydatidiform mole (HM) (complete and partial), invasive mole, gestational choriocarcinoma, placental-site ...
متن کاملTetraploidy in hydatidiform moles.
STUDY QUESTION How does tetraploidy develop in hydatidiform moles (HMs), and what is the frequency of the different origins? SUMMARY ANSWER Most molar pregnancies with tetraploid cells appear to be produced by somatic endoreduplications, while a minority originate from a tetraploid zygote. The frequency of zygotic tetraploidy was estimated to be 0.7%. WHAT IS KNOWN ALREADY The parental orig...
متن کاملSex chromatin of hydatidiform moles.
The placenta is a homograft which is tolerated by the host for an unusually long time. The hydatidiform mole may be said to be even more successful in this respect for it can survive longer and penetrate further in the host even in the absence of a viable foetus. Recent observations that a large number of hydatidiform moles are chromatin positive are of much interest, but so far the reported se...
متن کاملNLRP7 and the Genetics of Hydatidiform Moles: Recent Advances and New Challenges
NOD-like receptor proteins (NLRPs) are emerging key players in several inflammatory pathways in Mammals. The first identified gene coding for a protein from this family is Nlrp5 and was originally called Mater for "Maternal Antigen That Mouse Embryos Require" for normal development beyond the two-cell stage. This important discovery was followed by the identification of other NLRPs playing role...
متن کاملFounder Effect of KHDC3L, p.M1V Mutation, on Iranian Patients with Recurrent Hydatidiform Moles
Background: Recurrent hydatidiform moles (RHMs) are an unusual pregnancy with at least two molar gestations that are associated with abnormal proliferation of trophoblastic tissue and a failure in the embryonic tissues development. Three maternal-effect genes, including NLRP7, KHDC3L, and PADI6 have been identified as the cause of RHMs. The present study aimed to understand the association of a...
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ژورنال
عنوان ژورنال: Current Obstetrics and Gynecology Reports
سال: 2014
ISSN: 2161-3303
DOI: 10.1007/s13669-013-0076-1