Genetically Engineered Mouse Models of Pituitary Tumors

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Genetically Engineered Mouse Models of Pituitary Tumors

Animal models constitute valuable tools for investigating the pathogenesis of cancer as well as for preclinical testing of novel therapeutics approaches. However, the pathogenic mechanisms of pituitary-tumor formation remain poorly understood, particularly in sporadic adenomas, thus, making it a challenge to model pituitary tumors in mice. Nevertheless, genetically engineered mouse models (GEMM...

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ژورنال

عنوان ژورنال: Frontiers in Oncology

سال: 2014

ISSN: 2234-943X

DOI: 10.3389/fonc.2014.00203