Genetic Vulnerability and Susceptibility to Substance Dependence
نویسندگان
چکیده
منابع مشابه
Genetic Vulnerability and Susceptibility to Substance Dependence
The development of substance dependence requires the initiation of substance use and the conversion from experimental use to established use before development of dependence. Numerous large twin studies have indicated a significant genetic contribution to this process. Genetic studies to date have been most successful at identifying genetic factors that influence the transition from regular use...
متن کاملNo association between GSTM1 and GSTT1 genetic polymorphisms and susceptibility to opium sap dependence
Glutathione S-transferases (GSTs; EC: 2.5.1.18) are a ubiquitous family of eukaryotic and prokaryotic phase II metabolic isozymes. Genes encoding GSTM1 (OMIM: 138350), and GSTT1 (OMIM: 600436) are members of class mu and theta, respectively. The most common polymorphism in the GSTM1 is a deletion of the whole GSTM1 gene with a lack of enzyme activity. A homozygous deletion in the GSTT1 has also...
متن کاملno association between gstm1 and gstt1 genetic polymorphisms and susceptibility to opium sap dependence
glutathione s-transferases (gsts; ec: 2.5.1.18) are a ubiquitous family of eukaryotic and prokaryotic phase ii metabolic isozymes. genes encoding gstm1 (omim: 138350), and gstt1 (omim: 600436) are members of class mu and theta, respectively. the most common polymorphism in the gstm1 is a deletion of the whole gstm1 gene with a lack of enzyme activity. a homozygous deletion in the gstt1 has also...
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Neonatal diabetes mellitus (NDM) is a rare kind of diabetes characterized by hyperglycemia and low levels of insulin. Clinically, it is categorized into two main types: transient NDM (TNDM) and permanent NDM (PNDM). These types are diagnosed based on duration of insulin dependence early in the disease. In TNDM, diabetes begins in the first few weeks of life with remission in a few months. Howev...
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Introduction: CLL is one of the most common leukemias, which is categorized by the accumulation of mature CD5+ B-lymphocytes in the peripheral blood, bone marrow, and secondary lymphoid organs. In this study, the status of rs6449182 polymorphism of the CD38 gene and its association with clinical and laboratory parameters of CLL patients was evaluated. Methods: Genomic DNA extraction was perfor...
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ژورنال
عنوان ژورنال: Neuron
سال: 2011
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2011.02.015