Genetic variations and human health

Genetic Variations and Gastric Cancer

Background: Gastric cancer (GC) has an apparent hereditary component. However, in a large fraction of gastric cases, no known genetic syndrome or family history can be identified, suggesting the presence of ‘missing heritability’ in GC etiology. Genome-wide association studies (GWAS) and traditional candidate gene studies have both led to the identification of multiple replicable common genetic...

Magnitude of Human Genetic Variations: A Mini Review

Genetic variations are the genetic differences found among individuals of the same species. These variations are adaptive i.e. they ensure flexibility and survival of a population in the changing environment over time. It is quite interesting to know how and when these genetic variations offer to a population the survival benefit under the altered situations and at what extent over time. Whethe...

Functional characterization of genetic enzyme variations in human lipoxygenases☆

Mammalian lipoxygenases play a role in normal cell development and differentiation but they have also been implicated in the pathogenesis of cardiovascular, hyperproliferative and neurodegenerative diseases. As lipid peroxidizing enzymes they are involved in the regulation of cellular redox homeostasis since they produce lipid hydroperoxides, which serve as an efficient source for free radicals...

Genetic basis of photopigment variations in human dichromats

The spectral sensitivities of the X-encoded pigments in dichromats were studied using the electroretinogram. The action spectra measured for these subjects correspond to four distinctly different X-encoded visual pigments, two different middle-wave pigments spectrally separated by 7 nm and two different long-wave pigments separated by 5 nm. Amino acid sequences were deduced from examination of ...

Genetic and non-Genetic variations of body weight in iranian native fowl and their crosses with exotic breeds