Genetic Variation in Pneumocystis carinii Isolates from Different Geographic Regions: Implications for Transmission

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Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission.

To study transmission patterns of Pneumocystis carinii pneumonia (PCP) in persons with AIDS, we evaluated P. carinii isolates from patients in five U.S. cities for variation at two independent genetic loci, the mitochondrial large subunit rRNA and dihydropteroate synthase. Fourteen unique multilocus genotypes were observed in 191 isolates that were examined at both loci. Mixed infections, accou...

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Pneumocystis carinii is a major opportunistic pathogen which has been found in the lungs of a wide variety of mammalian host species, and the fact suggests the possibility of intraspecific variation. Until now, P. carinii from different mammalian species are differentiated as subspecies, and the rats are known to be infected by two subspecies. The present study investigated genetic heterogeneit...

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1. Beard CB, Fox MR, Lawrence GG, et al. Differences in Pneumocystis isolates recovered fromimmunocompetent infants and from adults with AIDS: epidemiological implications. J Infect Dis 2005; 192:1815–8. 2. Montes-Cano MA, de la Horra C, Martı́n-Juan J, et al. Pneumocystis jiroveci genotypes in the Spanish population. Clin Infect Dis 2004; 39: 123–8. 3. Beard CB, Carter JL, Keely SP, et al. Gene...

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ژورنال

عنوان ژورنال: Emerging Infectious Diseases

سال: 2000

ISSN: 1080-6040

DOI: 10.3201/eid0603.000306