Genetic Risk Scores

Multilocus Genetic Risk Scores for Venous Thromboembolism Risk Assessment

BACKGROUND Genetics plays an important role in venous thromboembolism (VTE). Factor V Leiden (FVL or rs6025) and prothrombin gene G20210A (PT or rs1799963) are the genetic variants currently tested for VTE risk assessment. We hypothesized that primary VTE risk assessment can be improved by using genetic risk scores with more genetic markers than just FVL-rs6025 and prothrombin gene PT-rs1799963...

Literature-Based Genetic Risk Scores for Coronary Heart Disease

Predictive accuracy of combined genetic and environmental risk scores

The substantial heritability of most complex diseases suggests that genetic data could provide useful risk prediction. To date the performance of genetic risk scores has fallen short of the potential implied by heritability, but this can be explained by insufficient sample sizes for estimating highly polygenic models. When risk predictors already exist based on environment or lifestyle, two key...

Aviation Relevance of Genetic Risk Scores for Cardiovascular Disease

Genetic Risk Scores Predict Recurrence of Acute Coronary Syndrome