منابع مشابه
Seeing beyond the double helix.
Epigenetics, or heritable changes not encoded in the DNA sequence, is a phenomenon important for an overall increase in the complexity of the genome without changes in gene sequence. Our complete genome is contained in each of our cells. Corneal cells are different than nerve cells due to a usage pattern of the genome that is maintained in a cellular memory of active or repressed genes. These “...
متن کاملMicrobial genome sequencing-beyond the double helix.
Considerable advances in automated DNA sequencing and bioinformatics have made the sequencing of entire microbial genomes a reality (see fig 1). Researchers have been quick to recognise the scientific value of microbial sequence data, and there is now a frantic rush to sequence a wide range of important micro-organisms. The continuing release of data from these projects, combined with advances ...
متن کاملBeyond the double helix: writing and reading the histone code.
Chromatin is the physiological carrier of not only genetic information, encoded in the DNA, but also of epigenetic information including DNA methylation and histone modifications. As such histone modifications are involved in many aspects of nuclear processes including gene regulation and chromosome segregation. Recently, a 'histone code' hypothesis was put forward to explain how patterns of hi...
متن کاملRemeasuring the double helix.
DNA is thought to behave as a stiff elastic rod with respect to the ubiquitous mechanical deformations inherent to its biology. To test this model at short DNA lengths, we measured the mean and variance of end-to-end length for a series of DNA double helices in solution, using small-angle x-ray scattering interference between gold nanocrystal labels. In the absence of applied tension, DNA is at...
متن کاملAging, double helix and small world property in genetic algorithms
Over a quarter of century after the invention of genetic algorithms and miriads of their modifications, as well as successful implementations, we are still lacking many essential details of thorough analysis of it’s inner working. One of such fundamental questions is how many generations do we need to solve the optimization problem? This paper tries to answer this question, albeit in a fuzzy wa...
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ژورنال
عنوان ژورنال: Journal of Medical Ethics
سال: 1984
ISSN: 0306-6800
DOI: 10.1136/jme.10.4.215