Genetic Polymorphism of CYP2C9 Among Sistani Ethnic Group in Gorgan
نویسندگان
چکیده
منابع مشابه
Genetic Polymorphism of Cytochrome P450 2C9 (CYP2C9) in Two Ethnic Groups in Iran
Cytochrome P450 2C9 is considered as a vital enzyme for drugs and toxic detoxification in human body. The present study was carried out to assess the distribution of CYP2C9 allele and genotypic variants in two ethnic groups (Fars and Turkman) in the North East of Iran. The present study contained 110 unrelated healthy Turkman origin and 110 unrelated healthy Fars origin people who were referred...
متن کاملGenetic Polymorphism of Cytochrome p450 (2C19) Enzyme in Iranian Turkman Ethnic Group.
OBJECTIVE Different findings indicate that CYP2C plays a clinical role in determining interindividual and interethnic differences in drug effectiveness. The ethnic differences in the frequency of CYP2C19 mutant alleles continue to be a significant study topic. The aim of the present study was to assess the frequency of allelic variants of CYP2C19 in Turkman ethnic groups and compare them with t...
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The aim of the present study is to assess and compare the frequencies of the cytochrome P450 CYP2C9 variations in the Baluch ethnic group (n=110) with other ethnic groups. The allele frequencies of CYP2C9*1, CYP2C9*2 and CYP2C9*3 were 80.90%, 11.82% and 7.27%, respectively. 70.90%, 11.82%, 8.18%, 4.55%, 2.73% and 1.82% of subjects were with CYP2C9*1/*1, CYP2C9*1/*2, CYP2C9*1/*3, CYP2C9*2/*2, CY...
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Losartan, an angiotensin II receptor antagonist, is oxidized by hepatic cytochromes P450 to an active carboxylic acid metabolite, E-3174. The aim of the present investigation was to study the contribution of CYP2C9 and CYP3A4 in losartan oxidation in vitro and to evaluate the role of CYP2C9 polymorphism. Kinetic properties of different genetic CYP2C9 variants were compared both in a yeast expre...
متن کاملGenetic polymorphism analyses of 30 InDels in Chinese Xibe ethnic group and its population genetic differentiations with other groups
In the present study, we obtained population genetic data and forensic parameters of 30 InDel loci in Chinese Xibe ethnic group from northwestern China and studied the genetic relationships between the studied Xibe group and other reference groups. The observed heterozygosities ranged from 0.1704 at HLD118 locus to 0.5247 at HLD92 locus while the expected heterozygosities ranged from 0.1559 at ...
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ژورنال
عنوان ژورنال: Indian Journal of Clinical Biochemistry
سال: 2017
ISSN: 0970-1915,0974-0422
DOI: 10.1007/s12291-017-0660-7