منابع مشابه
Signalling pathways and vascular calcification.
Vascular calcification is a major risk factor for cardiovascular morbidity and mortality. A full understanding of the signalling pathways mediating vascular calcification is crucial not just because of the importance of this pathology in disease, but also for exploring potential therapeutic targets. Clinically there is a need to develop therapies to prevent or even reverse calcification in situ...
متن کاملInflammatory, metabolic, and genetic mechanisms of vascular calcification.
This review centers on updating the active research area of vascular calcification. This pathology underlies substantial cardiovascular morbidity and mortality, through adverse mechanical effects on vascular compliance, vasomotion, and, most likely, plaque stability. Biomineralization is a complex, regulated process occurring widely throughout nature. Decades ago, its presence in the vasculatur...
متن کاملGenetics of vascular calcification.
Recessive mutations in the NTE5 gene were recently described in lower-extremity vascular calcification. ENPP1 mutations were previously described in a severe disorder of vascular calcification in infancy. Together these data support that extracellular adenosine and pyrophosphate are essential components of the pathways in vascular disease. Arterial calcification by impairing blood flow and redu...
متن کاملMechanism of vascular calcification
In the early 1900s, cholesterol deposition in atherosclerosis was considered a passive, degenerative, inevitable and end-stage process of ageing. After decades of research, it is now recognized as an active, regulated, treatable and preventable disorder related to deposition and oxidation of lipoprotein components. Similarly, in the past few decades, vascular calcification also has been conside...
متن کاملInflammation and Vascular Calcification Causing Effects of Oxidized HDL are Attenuated by Adiponectin in Human Vascular Smooth Muscle Cells
The role of oxidized high-density lipoprotein (oxHDL) and the protective effects of adiponectin in terms of vascular calcification is not well established. This study was conducted to investigate the effects of oxHDL with regards to inflammation and vascular calcification and to determine the protective role of adiponectin in attenuating the detrimental effects of oxHDL. Cell viability, mineral...
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ژورنال
عنوان ژورنال: Trends in Cardiovascular Medicine
سال: 2012
ISSN: 1050-1738
DOI: 10.1016/j.tcm.2012.07.002