منابع مشابه
Genetic modification of somatic stem cells
Some of the illnesses that plague man kind are directly related to our genes. Severe genetic disorders with no current therapeutic options—immuno deficiencies, haemophilia, thalassaemia, muscular dystrophies and cystic fibrosis, for example—could potentially be treated with gene therapy, which uses genetic informa tion to correct a mutation or to provide new functions for human cells. the ai...
متن کاملGenetic modification of human embryonic stem cells.
Abbreviations: Ad: adenovirus, bFGF: basic fibroblast growth factor, BMP: bone morphogenetic protein, CNS: central nervous system, ES: embryonic stem, FACS: fluorescence activated cell sorting, HIV: human immunodeficiency virus, ICM: inner cell mass, LIF: leukemia inhibitory factor, MEF: mouse embryonic fibroblast, RNAi: RNA interference, SCNT: somatic cell nucleus transfer, UTR: untranslated r...
متن کاملI-31: Reconstruction of Human Endometrium from Somatic Stem Cells
s:3115:"Background: During reproductive life, the human endometrium undergoes around 500 cycles of growth, breakdown and regeneration. This outstanding regenerative capability is the basis for cyclic endometrial preparation and its dysfunction is involved in pathological disorders. Endometrial regeneration is mediated by the existence of a specialized endometrial stem cell (SC) population recen...
متن کاملhistone modification of embryonic stem cells produced by somatic cell nuclear transfer and fertilized blastocysts
objective: nuclear transfer-embryonic stem cells (nt-escs) are genetically identical to the donor’s cells; provide a renewable source of tissue for replacement, and therefore, decrease the risk of immune rejection. trichostatin a (tsa) as a histone deacetylase inhibitor (hdaci) plays an important role in the reorganization of the genome and epigenetic changes. in this study, we examined whether...
متن کاملDifferentiation of Somatic Unrestricted Cord Blood Stem Cells into Chondrocyte Cells
Purpose: To isolate and purify unrestricted somatic stem cells from human umbilical cord blood and evaluation of their differentiation into chondrocyte in vitro.Materials and Methods: In this study cells from human umbilical cord blood were isolated and plated in flask. Colonies were performed after one week. To determine the kind of cells, 100000 cells were analysed with flowcytometry. Twenty ...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2008
ISSN: 1469-221X,1469-3178
DOI: 10.1038/embor.2008.81