منابع مشابه
Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights.
Insights concerning leukemic pathophysiology have been acquired in various animal models and further efforts to understand the mechanisms underlying leukemic treatment resistance and disease relapse promise to improve therapeutic strategies. The zebrafish (Danio rerio) is a vertebrate organism with a conserved hematopoietic program and unique experimental strengths suiting it for the investigat...
متن کاملphylogeography and genetic diversity of the lesser mouse- eared bat (myotis blythii) in iran
in current study, 63 samples of bat populations collected from differ regions were used for evaluating the geographic variations. twenty cranial and dental characters for traditional morphometric and landmarks method on the ventral, dorsal skull and mandible for geometry morphometric studies were used. statistical analyses of traditional morphometric and geometry morphometric data indicated low...
Speed of leukemia development and genetic diversity in xenograft models of T cell acute lymphoblastic leukemia
T cell acute lymphoblastic leukemia (T-ALL) develops through accumulation of multiple genomic alterations within T-cell progenitors resulting in clonal heterogeneity among leukemic cells. Human T-ALL xeno-transplantation in immunodeficient mice is a gold standard approach to study leukemia biology and we recently uncovered that the leukemia development is more or less rapid depending on T-ALL s...
متن کاملGenetic variation in the zebrafish.
Although zebrafish was introduced as a laboratory model organism several decades ago and now serves as a primary model for developmental biology, there is only limited data on its genetic variation. An establishment of a dense polymorphism map becomes a requirement for effective linkage analysis and cloning approaches in zebrafish. By comparing ESTs to whole-genome shotgun data, we predicted >5...
متن کاملBuilding bridges with zebrafish : highlights of the ‘ Zebrafish Models in
biomedical research, EuFishBioMed (www.eufishbiomed.kit.edu/) and ZF-HEALTH (zf-health.org/) recently joined forces to organise a meeting with the primary aim of forging collaborations between the established ‘zebrafish community’ and newcomers that hope the model will shed light on unanswered questions in their disease area. The 3-day meeting, ‘Zebrafish Models in Translational Medicine’, whic...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2018
ISSN: 2296-634X
DOI: 10.3389/fcell.2018.00115