Genetic linkage analysis using lognormal variance components
نویسندگان
چکیده
منابع مشابه
Variance components linkage analysis with repeated measurements.
BACKGROUND When subjects are measured multiple times, linkage analysis needs to appropriately model these repeated measures. A number of methods have been proposed to model repeated measures in linkage analysis. Here, we focus on assessing the impact of repeated measures on the power and cost of a linkage study. METHODS We describe three alternative extensions of the variance components appro...
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Variance components models were used to analyze total IgE levels in families ascertained though the Collaborative Study of the Genetics of Asthma (CSGA) using a genome-wide array of polymorphic markers. While IgE levels are known to be associated with clinical asthma and recognized to be under strong genetic control (here the heritability was estimated at 44-60% in the three racial groups), spe...
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Genetic linkage analysis is a statistical method for mapping genes onto chromosomes, and is useful for detecting and predicting diseases. One of its current limitations is the computational complexity of the problems of interest. This research presents methods for mapping genetic linkage problems as Bayesian networks and then addresses novel techniques for making the problems more tractable. Th...
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ژورنال
عنوان ژورنال: Annals of Human Genetics
سال: 1998
ISSN: 0003-4800,1469-1809
DOI: 10.1046/j.1469-1809.1998.6260521.x