منابع مشابه
Genetic homogeneity of cystic fibrosis.
We studied large Amish/Mennonite/Hutterite kindreds that segregate cystic fibrosis (CF) for linkage between CF and the polymorphic DNA markers pJ3.11 and 7C22 located on chromosome 7. These inbred pedigrees consist of more than 300 members including 30 affected individuals. In these families, linkage between the CF locus and the chromosome 21 marker D21S5 and between CF and the marker at the me...
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We apply the modified likelihood ratio test to two binomial mixture models arising in genetic linkage analysis. The limiting distribution of the test statistic for both models is shown to be a mixture of chi-squared distributions. A consideration of random family sizes for both models gives similar results. We also explore the power properties under local alternatives. Simulation studies show t...
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implicit and unobserved errors and vulnerabilities issues usually arise in cryptographic protocols and especially in authentication protocols. this may enable an attacker to make serious damages to the desired system, such as having the access to or changing secret documents, interfering in bank transactions, having access to users’ accounts, or may be having the control all over the syste...
15 صفحه اولGenetic background of clinical homogeneity of phenylketonuria in Poland.
In order to elucidate the clinical homogeneity and severity of the hyperphenylalaninaemias in Poland, a total of 71 children with typical phenylketonuria (PKU) originating from western and northern Poland were screened for 13 mutations in the phenylalanine hydroxylase (PAH) gene. Eighty percent of all PKU alleles tested were found to carry an identified mutation. One mutation, namely the R408W ...
متن کاملWhole genome characterization of sequence diversity of 15,220 Icelanders
Understanding of sequence diversity is the cornerstone of analysis of genetic disorders, population genetics, and evolutionary biology. Here, we present an update of our sequencing set to 15,220 Icelanders who we sequenced to an average genome-wide coverage of 34X. We identified 39,020,168 autosomal variants passing GATK filters: 31,079,378 SNPs and 7,940,790 indels. Calling de novo mutations (...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2000
ISSN: 1061-4036,1546-1718
DOI: 10.1038/82508