Genetic Heterogeneity in Breast Cancer
نویسندگان
چکیده
منابع مشابه
Genetic heterogeneity in breast cancer: the road to personalized medicine?
More women die from breast cancer across the world today than from any other type of malignancy. The clinical course of breast cancer varies tremendously between patients. While some of this variability is explained by traditional clinico-pathological factors (including patient age, tumor stage, histological grade and estrogen receptor status), molecular profiling studies have defined breast ca...
متن کاملHeterogeneity in breast cancer.
Breast cancer is a heterogeneous disease. There is a high degree of diversity between and within tumors as well as among cancer-bearing individuals, and all of these factors together determine the risk of disease progression and therapeutic resistance. Advances in technologies such as whole-genome sequencing and functional viability screens now allow us to analyze tumors at unprecedented depths...
متن کاملHeterogeneity in Breast cancer
Breast cancer is malignant tumor occurred on breast epithelial tissue, although the mortality rate of breast cancer decreases, it remains one of the highest mortality rate diseases. Ignoring few exceptions, almost all tumors are derived from one single cancer cell. However, in clinical diagnosis, most human tumors demonstrate amazing heterogeneity in many morphological and physical characterist...
متن کاملGenetic polymorphism in ERCC5 and breast cancer risk
ERCC5 plays crucial role in excision repair DNA damage induced by UV in NER pathway. Single neuleotide polymorphism in ERCC5 were responsible for different cancers.Therefore, current study evaluated the relationship between ERCC5 (rs1047768 T>C) polymorphism and the risk of breast cancer in Pakistani population. The rs1047768 polymorphism was screened among 175 female...
متن کاملGenetic polymorphism in ERCC5 and breast cancer risk
ERCC5 plays crucial role in excision repair DNA damage induced by UV in NER pathway. Single neuleotide polymorphism in ERCC5 were responsible for different cancers.Therefore, current study evaluated the relationship between ERCC5 (rs1047768 T>C) polymorphism and the risk of breast cancer in Pakistani population. The rs1047768 polymorphism was screened among 175 female...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 1992
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/84.7.469