Genetic Differences in Endothelial Cells May Determine Atherosclerosis Susceptibility
نویسندگان
چکیده
منابع مشابه
Genetic differences in endothelial cells may determine atherosclerosis susceptibility.
Atherosclerotic cardiovascular disease is a complex genetic disorder that involves many genes and has significant gene-environment interactions. The extensive study of candidate genes in pathways relevant to atherosclerotic cardiovascular disease risk factors has had limited success in explaining the population’s susceptibility to this disease. With the advent of the Genome Program, it is now b...
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BACKGROUND Oxidized LDL has been found within the subendothelial space, and it exhibits numerous atherogenic properties, including induction of inflammatory genes. We examined the possibility that variations in endothelial response to minimally modified LDL (MM-LDL) constitute one of the genetic components in atherosclerosis. METHODS AND RESULTS By a novel explant technique, endothelial cells...
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ژورنال
عنوان ژورنال: Circulation
سال: 2000
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.102.1.5