Genetic Counseling in a Couple with Primary Infertility

Background: Couples unable to conceive and bear children could feel deep disappointment, often leading depression. Infertility is one of the main reasons couples are not able have children. Genetic counseling role in infertility ranges from explanation about possible genetic causes infertility, pregnancy planning, advice for treatment. Case Presentation: A couple with 16 years was referred clinic at National Diponegoro Hospital. The 42 old female had previous history diabetes mellitus, obesity, treatment epilepsy/seizure 15 ago routine carbamazepine therapy 2 years, while her husband active hepatitis B infection years. This underwent insemination program twice once completed In Vitro Fertilization (IVF), both management bearing no successful implantation or viable pregnancy. Recently, she a laparoscopy procedure, which gave new diagnosis endometriosis adenomyosis. Chromosomal examination Methylenetetrahydrofolate Reductase (MTHFR) C677T A1298C alleles analysis were done our laboratory. Both individuals carried normal karyotypes MTHFR homozygote wild type allele. Currently, this has accepted their conditions. They still want child although crucial ageConclusion: challenging comprehensive problem. As healthcare professionals, we encounter problems only management, but also psychological emotional dilemma. needed solve avoid patient’s distress.