Genetic architecture underlying the native collateral circulation

Genetic architecture underlying variation in extent and remodeling of the collateral circulation.

RATIONALE Collaterals are arteriole-to-arteriole anastomoses that connect adjacent arterial trees. They lessen ischemic tissue injury by serving as endogenous bypass vessels when the trunk of 1 tree becomes narrowed by vascular disease. The number and diameter ("extent") of native (preexisting) collaterals, plus their amount of lumen enlargement (growth/remodeling) in occlusive disease, show re...

The myocardial collateral circulation.

Collateral circulation.

BACKGROUND The collateral circulation plays a pivotal role in the pathophysiology of cerebral ischemia. Current knowledge of the collateral circulation remains sparse, largely because of prior limitations in methods for evaluation of these diminutive routes of cerebral blood flow. SUMMARY OF REVIEW Anatomic descriptions of the collateral circulation often focus on more proximal anastomoses at...

The human coronary collateral circulation.

BACKGROUND Coronary collaterals are an alternative source of blood supply to myocardium jeopardized by ischaemia. Well-developed coronary collateral arteries in patients with coronary artery disease (CAD) mitigate myocardial infarcts and improve survival. METHODS AND RESULTS Collateral arteries preventing myocardial ischaemia during brief vascular occlusion are present in 1/3 of patients with...

Dynamics of the Collateral Circulation

W HEN the proximal portion of the subclavian artery is occluded, numerous anastomotic vessels in the neck and chest wall are available to maintain the circulation to the arm." 2 Another collateral pathway, consisting of both vertebral arteries,3 has recently created much interest. Contorni4 showed, by the use of selective arteriography, that dye passed up the right vertebral artery to its junct...