Genetic and epigenetic architecture of Obsessive-Compulsive Disorder: In search of possible diagnostic and prognostic biomarkers

Obsessive-Compulsive Disorder (OCD) is a prevalent and severe clinical condition whose hallmarks are excessive, unwanted thoughts (obsessions) repetitive behaviors (compulsions). The onset of symptoms generally occurs during pre-adult life typically affects subjects in different aspects their life's, compromising social professional relationships. Although robust evidence suggests genetic component the etiopathogenesis OCD, causes disorder still not completely understood. It thus relevance to take into account how genes interact with environmental risk factors, thought be mediated by epigenetic mechanisms. We here provide an overview mechanisms focusing on modulation key central nervous system genes, attempt suggest possible disease biomarkers.