Genetic and Epigenetic Abnormalities in Primary Sclerosing Cholangitis-associated Cholangiocarcinoma
نویسندگان
چکیده
منابع مشابه
Cholangiocarcinoma in primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown causes closely associated with ulcerative colitis. PSC is a progressive disease leading to liver failure and need for liver transplantation. Cholangiocarcinoma (CC) occurs in 10 20% of patients with PSC. The prognosis for CC is poor, even after liver transplantation. It is of great importance to identify PS...
متن کاملGenetic Abnormalities in Biliary Brush Samples for Distinguishing Cholangiocarcinoma from Benign Strictures in Primary Sclerosing Cholangitis
Background. Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease and is strongly associated with cholangiocarcinoma (CCA). The lack of efficient diagnostic methods for CCA is a major problem. Testing for genetic abnormalities may increase the diagnostic value of cytology. Methods. We assessed genetic abnormalities for CDKN2A, TP53, ERBB2, 20q, MYC, and chromosomes 7 and ...
متن کاملA case of intrahepatic cholangiocarcinoma associated with primary sclerosing cholangitis.
A 31-year-old man was referred to our hospital for the treatment of obstructive jaundice. Dynamic CT scan revealed an ill-defined mass in the right liver, 4.0 3.5 cm in size, involving the right branch of the portal vein (Fig. 1A). Percutaneous transhepatic cholangiogram showed widespread biliary stricture in the left liver (Fig. 1B), which suggested primary sclerosing cholangitis (PSC) or IgG4...
متن کاملImmunoglobulin G4-associated sclerosing cholangitis mimicking cholangiocarcinoma.
Immunoglobulin G4-related lymphoplasmacytic sclerosing disease is an emerging disease. Recently, it has been shown to be responsible for autoimmune pancreatitis-induced strictures of the bile duct mimicking cholangiocarcinoma. Making a diagnosis of immunoglobulin G4-associated sclerosing cholangitis requires a high index of suspicion. The differential diagnoses include primary sclerosing cholan...
متن کاملp53 Protein overexpression in cholangiocarcinoma arising in primary sclerosing cholangitis.
The protein encoded by the p53 tumour suppressor gene plays an important part in the regulation of cell growth. Abnormalities of this gene represent one of the most common genetic changes in the development of human cancers. This study investigated the expression of p53 protein in cholangiocarcinoma arising in association with primary sclerosing cholangitis (PSC). Of the 14 patients with cholan...
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ژورنال
عنوان ژورنال: Inflammatory Bowel Diseases
سال: 2013
ISSN: 1078-0998
DOI: 10.1097/mib.0b013e318281f49a