Genetic ancestry modifies pharmacogenetic gene–gene interaction for asthma
نویسندگان
چکیده
منابع مشابه
Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthma.
OBJECTIVE A recent admixture mapping analysis identified interleukin 6 (IL6) and IL6 receptor (IL6R) as candidate genes for inflammatory diseases. In the airways during allergic inflammation, IL6 signaling controls the production of proinflammatory and anti-inflammatory factors. In addition, albuterol, a commonly prescribed asthma therapy, has been shown to influence IL6 gene expression. Theref...
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The human genome is a mosaic with respect to its evolutionary history. Based on a phylogenetic analysis of 23,210 DNA sequence alignments from human, chimpanzee, gorilla, orangutan, and rhesus, we present a map of human genetic ancestry. For about 23% of our genome, we share no immediate genetic ancestry with our closest living relative, the chimpanzee. This encompasses genes and exons to the s...
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The genealogical ancestors to an individual are the the individuals that can be reached by a string of operators mother/father to that individual, like motherfatherfather. Within that set are the individuals, that has genetic material that was transmitted to the present individual. Genetic ancestry is in general given more attention as that is a component in genetic analysis and mapping, while ...
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Recent statistical and computational analyses have shown that a genealogical most recent common ancestor (MRCA) may have lived in the recent past [Chang, J.T., 1999. Recent common ancestors of all present-day individuals. Adv. Appl. Probab. 31, 1002-1026. 1027-1038; Rohde, D.L.T., Olson, S., Chang, J.T., 2004. Modelling the recent common ancestry of all living humans. Nature 431, 562-566]. Howe...
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It is hard to believe that as recently as a decade ago, some of us were finding it virtually impossible to get an epidemiologic study funded from the National Cancer Institute if it required collection and analysis of DNA. Now, it is virtually impossible to get anything funded if you do not! The rapid transformation of epidemiology into the molecular world has been so swift and dramatic that by...
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ژورنال
عنوان ژورنال: Pharmacogenetics and Genomics
سال: 2009
ISSN: 1744-6872
DOI: 10.1097/fpc.0b013e32832c440e