Genetic analysis of lobular carcinoma in situ and associated invasive lobular cancer

Clonality of lobular carcinoma in situ and synchronous invasive lobular carcinoma.

BACKGROUND Lobular carcinoma in situ (LCIS) of the breast is considered a marker for an increased risk of carcinoma in both breasts. However, the frequent association of LCIS with invasive lobular carcinoma (ILC) suggests a precursor-product relation. The possible genomic relation between synchronous LCIS and ILC was analyzed using the technique of array-based comparative genomic hybridization ...

Genetic relation of lobular carcinoma in situ, ductal carcinoma in situ, and associated invasive carcinoma of the breast.

AIMS The mutual relation of lobular carcinoma in situ (LCIS) and ductal carcinoma in situ (DCIS) of the breast, as accepted precursor lesions of invasive breast cancer, is controversial. Because they display genetic heterogeneity, it is not clear how genetically advanced these entities are and what causes the transition to an invasive carcinoma. METHODS Six cases of LCIS, four of them with as...

Relapse of invasive lobular carcinoma.

Genetic Predisposition to In Situ and Invasive Lobular Carcinoma of the Breast

Invasive lobular breast cancer (ILC) accounts for 10-15% of all invasive breast carcinomas. It is generally ER positive (ER+) and often associated with lobular carcinoma in situ (LCIS). Genome-wide association studies have identified more than 70 common polymorphisms that predispose to breast cancer, but these studies included predominantly ductal (IDC) carcinomas. To identify novel common poly...

Invasive lobular carcinoma of the breast.

The classical pattern of invasive lobular carcinoma (ILC) has become well established since the tumour was first designated in the 1940's. It is a distinct histological type of breast cancer, yet the incidence rates accumulated from the literature are widely divergent and vary from 0.7-20 per cent,' suggesting the criteria for diagnosis are not well defined. Martinez and Azzopardil in the only ...