Genetic analysis of hypermelanosis in Chinese tongue sole (Cynoglossus semilaevis)

Chinese tongue sole ( Cynoglossus semilaevis ) is an economically important marine fish in China. Generally, the eyeless side of white and with eyes brown after metamorphosis, hypermelanosis may still occur certain individuals which greatly decreases consumer acceptance market price. In order to study possibility genetic improvement, we determined genomic markers using genotyping-by-sequencing method analyzed their association area. Genetic analysis showed that was a complicated quantitative trait, estimated heritability for incidence area ratio were 0.16 0.21, respectively. Genomic selection based on had similar reliabilities prediction accuracies, indicating feasibility improvement. Nine loci significantly associated hypermelanosis, few included genes or flanked potentially skin disease, potential mechanisms underlying sole.