Genetic analysis of early onset familial coronary artery diseases

GATA2 Is Associated with Familial Early-Onset Coronary Artery Disease

The transcription factor GATA2 plays an essential role in the establishment and maintenance of adult hematopoiesis. It is expressed in hematopoietic stem cells, as well as the cells that make up the aortic vasculature, namely aortic endothelial cells and smooth muscle cells. We have shown that GATA2 expression is predictive of location within the thoracic aorta; location is suggested to be a su...

Evaluation of Genome in Early Familial Coronary Artery Disease: A Case Report

Background and Objectives: Coronary artery diseases (CAD) are the most common cause of death in Iran and worldwide. Myocardial infarction (MI) is a complex multifactorial and the most severe type of CAD. Early onset MI in first degree relatives could be considered as an independent risk factor for CAD. This study was performed to investigate the genetic cause of early onset familial CAD.   Cas...

Genetic Mutations that Cause Coronary Artery Disease

Familial spontaneous coronary artery dissection: evidence for genetic susceptibility.

IMPORTANCE Spontaneous coronary artery dissection (SCAD) is a major cause of acute coronary syndrome in young women, especially among those without traditional cardiovascular risk factors. Prior efforts to study SCAD have been hampered by underrecognition and lack of registry-based studies. Risk factors and pathogenesis remain largely undefined, and inheritability has not been reported. OBSER...

Coronary Artery Disease: Markers of Severity and Early Onset

Coronary Artery Disease (CAD) is a multifactorial disease with acquired and inherited components. This study aim was to evaluate the function of MPO in discriminating angiographic CAD result, to demonstrate the role of SNPs 599839-12487736 in early onset of CAD and to isolate the role of genetics by exploring the concomitant effect of consanguinity and disease family history in determining risk...