Genetic Abnormalities, Clonal Evolution, and Cancer Stem Cells of Brain Tumors
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چکیده
منابع مشابه
Ovarian Cancers: Genetic Abnormalities, Tumor Heterogeneity and Progression, Clonal Evolution and Cancer Stem Cells
Four main histological subtypes of ovarian cancer exist: serous (the most frequent), endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large majority of ovarian cancers are diagnosed as high-grade serous ovarian cancers (HGS-OvCas). TP53 is the most frequently mutated gene in HGS-OvCas; about 50% of these tumors displayed defective homologous recombination due to g...
متن کاملLiver Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells
Liver cancer is the second most common cause of cancer-related death. The major forms of primary liver cancer are hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). Both these tumors develop against a background of cirrhotic liver, non-alcoholic fatty liver disease, chronic liver damage and fibrosis. HCC is a heterogeneous disease which usually develops within liver cirr...
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Pancreatic Ductal Adenocarcinoma (PDAC) is the fourth most common cause of cancer-related death and is the most lethal of common malignancies with a five-year survival rate of <10%. PDAC arises from different types of non-invasive precursor lesions: intraductal papillary mucinous neoplasms, mucinous cystic neoplasms and pancreatic intraepithelial neoplasia. The genetic landscape of PDAC is char...
متن کاملTitle: Cancer Stem Cells and Brain Tumors
Besides the role that normal stem cells play in organogenesis, cancer stem cells are thought to be crucial for tumorigenesis. Most current research on human tumors is focused on the molecular and cellular analysis of the bulk tumor mass. However, evidence in leukemia and, more recently, in solid tumors suggests that the tumor cell population is heterogeneous. During the last years, several grou...
متن کاملHeterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution
The identification and characterization of cancer stem cells might lead to more effective treatments for some cancers by focusing therapy on the most malignant cells. To achieve this goal it will be necessary to determine which cancers follow a cancer stem cell model and which do not, to address technical issues related to tumorigenesis assays, and to test the extent to which cancer cell hetero...
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ژورنال
عنوان ژورنال: Medical Sciences
سال: 2018
ISSN: 2076-3271
DOI: 10.3390/medsci6040085