Generation of Multiple Stable Dermcidin-Derived Antimicrobial Peptides in Sweat of Different Body Sites

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Generation of multiple stable dermcidin-derived antimicrobial peptides in sweat of different body sites.

Antimicrobial peptides (AMPs) are effector molecules of innate immunity. Dermcidin (DCD), a recently discovered AMP with broad-spectrum activity, is produced constitutively by the eccrine sweat glands and secreted into sweat. In this study, we investigated the proteolytic processing, site-specific expression, and stability of DCD peptides in eccrine sweat. Using surface-enhanced laser desorptio...

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10.1021/bi0160516 CCC: $22.00 © 2002 American Chemical Society Published on Web 04/01/2002 ABSTRACT: Dermcidin (DCD), an recently discovered antimicrobial peptide, plays a role in the innate response by regulating human skin flora in sweat. Here we describe the isolation of the gene of a variant of dermcidin, designated as DCD-α. This variant has 75% homology to dermcidin and has been found in ...

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ژورنال

عنوان ژورنال: Journal of Investigative Dermatology

سال: 2006

ISSN: 0022-202X

DOI: 10.1038/sj.jid.5700041