Generation of multiple iPSC clones from a male schizophrenia patient carrying de novo mutations in genes KHSRP, LRRC7, and KIR2DL1, and his parents

Here we describe the generation of induced pluripotent stem cell lines from each member - male proband, mother, father a schizophrenia case-parent trio that participated in an exome sequencing study, and 3 de novo mutations were identified proband. Peripheral blood mononuclear cells obtained all three individuals reprogrammed using Sendai virus particles carrying Yamanaka transgenes. These iPSC (iPSC-SZ-HU-MO 1, iPSC-SZ-HU-FA iPSC-SZ-HU-PROB 1) represent resource for examining functional significance molecular pathophysiology schizophrenia.