General Anesthetics Have Additive Actions on Three Ligand Gated Ion Channels
نویسندگان
چکیده
منابع مشابه
Actions of anesthetics on ligand-gated ion channels: role of receptor subunit composition.
Molecular cloning of cDNAs coding for ligand-gated ion channel subunits makes it possible to study the pharmacology of recombinant receptors with defined subunit compositions. Many laboratories have used these techniques recently to study actions of agents that produce general anesthesia. We review the effects of volatile and intravenous anesthetics on recombinant GABAA, glycine, AMPA, kainate,...
متن کاملIntravenous anesthetics differentially modulate ligand-gated ion channels.
BACKGROUND Heteromeric neuronal nicotinic acetylcholine receptors (nAChRs) are potently inhibited by volatile anesthetics, but it is not known whether they are affected by intravenous anesthetics. Ketamine potentiates gamma-aminobutyric acid type A (GABAA) receptors at high concentrations, but it is unknown whether there is potentiation at clinically relevant concentrations. Information about t...
متن کاملThe effects of general anaesthetics on ligand-gated ion channels.
The experimental effort that has been expended in investigating the effects of general anaesthetics on LGICs has been enormous over the past decade. Members of all three LGIC superfamilies have been examined using electrophysiological techniques. Anaesthetics that have been examined include volatile anaesthetics, gaseous anaesthetics, alcohols, i.v. anaesthetics and non-immobilizers. Obsolete a...
متن کاملEffects of general anaesthetics on ligand-gated ion channels.
The site at which anaesthetics act within the central nervous system (CNS) has been the subject of research for almost 100 years. Most success has been obtained in defining the physical nature of the site [70]. For example, the well established correlation of anaesthetic potency to fat solubility indicates that the site of action is hydrophobic. Research using anaesthetics with unusual solubili...
متن کاملSeeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.
Alcohols and other anesthetic agents dramatically alter neurologic function in a wide range of organisms, yet their molecular sites of action remain poorly characterized. Pentameric ligand-gated ion channels, long implicated in important direct effects of alcohol and anesthetic binding, have recently been illuminated in renewed detail thanks to the determination of atomic-resolution structures ...
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ژورنال
عنوان ژورنال: Anesthesia & Analgesia
سال: 2008
ISSN: 0003-2999
DOI: 10.1213/ane.0b013e31817b70c1