General Anesthetics and Molecular Mechanisms of Unconsciousness
نویسندگان
چکیده
منابع مشابه
General anesthetics and molecular mechanisms of unconsciousness.
The term ‘‘anesthesia’’ was originally used by the ancient Greek surgeon Dioscorides and resurrected by Dr Oliver Wendell Holmes to describe the insensible state produced by inhalation of ether. The goals of general anesthesia include amnesia, unconsciousness (also termed hypnosis), and immobilization. By definition, general anesthetics reversibly produce all 3 of these therapeutic effects. Gen...
متن کاملCorrelating the clinical actions and molecular mechanisms of general anesthetics.
PURPOSE OF REVIEW To summarize recent in-vitro and in-vivo research on molecular mechanisms of general anesthetics' actions. RECENT FINDINGS Classes of general anesthetics with distinct clinical profiles appear to induce amnesia, hypnosis, and immobility via different molecular targets. Propofol, etomidate, and barbiturates produce profound amnesia and hypnosis, but weak immobility, by enhanc...
متن کاملMechanisms of action of general anesthetics.
Since William Morton successfully demonstrated the use of inhaled ether for surgical anesthesia in 1846, the development of new anesthetics and safe general anesthesia techniques have contributed greatly to the advancement of surgery and other invasive procedures. However, the underlying neurocellular mechanisms by which the state of general anesthesia is achieved are only just beginning to be ...
متن کاملMolecular Targets of General Anesthetics in the Nervous System
Current concepts of the molecular and cellular mechanisms that underlie general anesthetic actions are incomplete. This is both surprising, given that leading scientists have approached this problem for more than a century, and unfortunate since this lack of knowledge limits our ability to employ these important drugs with optimal safety and efficacy. Considerable evidence now implicates agent-...
متن کاملMolecular mechanisms of general anesthesia
General anesthetics produce a widespread neurodepression in the central nervous system by enhancing inhibitory neurotransmission and reducing excitatory neurotransmission. However, the action mechanisms of general anesthetics are not completely understood. Moreover, the general anesthetic state comprises multiple components (amnesia, unconsciousness, analgesia, and immobility), each of which is...
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ژورنال
عنوان ژورنال: International Anesthesiology Clinics
سال: 2008
ISSN: 0020-5907
DOI: 10.1097/aia.0b013e3181755da5