منابع مشابه
Why a Special Issue on Gene Therapy?
Going both from the organism to the DNA and from the DNA to the organism, the biology of the 20th century has paved the way for a new type of biologist who has emerged from the laboratory during the last two decades: the gene therapist. At the beginning of the nineties, much of this young field was based on a relatively simple concept: a deficient function can be replaced with an artificial gen...
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Two months into my intern year I experienced something that I thought only happened on television. It was 3 a.m. on a relatively uneventful night shift. Being one of the newest residents working that evening I expected to get the less desirable cases, and this one felt no different. A new patient showed up on the grease board: a 22-year-old female with a chief complaint of constipation. “Sounds...
متن کاملNon-Viral Delivery Systems in Gene Therapy
Recent advances in molecular biology combined with the culmination of the Human Ge‐ nome Project [1] have provided a genetic understanding of cellular processes and disease pathogenesis; numerous genes involved in disease and cellular processes have been identi‐ fied as targets for therapeutic approaches. In addition, the development of high-throughput screening techniques (e.g., cDNA microarra...
متن کاملNanoparticle-mediated drug delivery and gene therapy.
Biomedical application of nanotechnology is a rapidly developing area that raises new prospect in the improvement of diagnosis and treatment of human diseases. The ability to incorporate drugs or genes into a functionalized nanoparticle demonstrates a new era in pharmacotherapy for delivering drugs or genes selectively to tissues or cells. It is envisioned that the transfer of nanoengineering c...
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This chapter examines key concepts with respect to cancer gene therapy and the cur‐ rent issues with respect to non-viral delivery. The biological and molecular barriers that need to be overcome before effective non-viral delivery systems can be appropri‐ ately designed for oncology applications are highlighted and ways to overcome these are discussed. Strategies developed to evade the immune r...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2004
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc1394