منابع مشابه
Gene Therapy for Retinal Diseases
Gene therapy has a growing research potential particularly in the field of ophthalmic and retinal diseases owing to three main characteristics of the eye; accessibility in terms of injections and surgical interventions, its immune-privileged status facilitating the accommodation to the antigenicity of a viral vector, and tight blood-ocular barriers which save other organs from unwanted contamin...
متن کاملGene therapy to treat inherited and complex retinal degenerative diseases
These are exciting times in the field of retinal gene therapy, as impressive successes have been achieved by recombinant adenoassociated viral (rAAV) gene delivery of Rpe65 or Rep1 to the retinal pigment epithelium of patients with Lebers congential amaurosis or choroideremia, respectively.1–5 Instead of being left with incurable blindness, patients are reporting restoration of vision. An advan...
متن کاملStem-Cell Therapy for Retinal Diseases
1.1 Stem cell (SC) therapy is not a new concept. In the aftermath of the bombings of Hiroshima and Nagasaki in 1945, researchers discovered that bone marrow transplanted into irradiated mice produced hematopoiesis (Lorenz, 1951). Hematopoietic stem cells (HSCs) were first identified in 1961 and their ability to migrate and differentiate into multiple cell types was documented (Till, 1961). Dist...
متن کاملStem cell therapy for retinal diseases.
In this review, we discuss about current knowledge about stem cell (SC) therapy in the treatment of retinal degeneration. Both human embryonic stem cell and induced pluripotent stem cell has been growth in culture for a long time, and started to be explored in the treatment of blinding conditions. The Food and Drug Administration, recently, has granted clinical trials using SC retinal therapy t...
متن کاملGene therapy for infectious diseases.
Gene therapy is being investigated as an alternative treatment for a wide range of infectious diseases that are not amenable to standard clinical management. Approaches to gene therapy for infectious diseases can be divided into three broad categories: (i) gene therapies based on nucleic acid moieties, including antisense DNA or RNA, RNA decoys, and catalytic RNA moieties (ribozymes); (ii) prot...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Ophthalmic and Vision Research
سال: 2014
ISSN: 2008-322X
DOI: 10.4103/2008-322x.150831