Gene targeting: Applications in transplantation research
نویسندگان
چکیده
منابع مشابه
Targeting Thyroid Cancer Microenvironment: Basic Research and Clinical Applications
INTRODUCTION Thyroid cancer is the most common endocrine malignancy and its incidence has increased considerably over the past few decades (1). This Research Topic is devoted to understanding the molecular mechanism of human thyroid cancer, with an emphasis on translation to the clinic. The original research papers assembled here probe the pathogenetic pathway from a wide range of approaches, i...
متن کاملTargeting therapeutic vector expression and integration for gene therapy applications
Approved: ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date 1 TARGETING THERAPEUTIC VECTOR EXPRESSION AND INTEGRATION FOR GENE THERAPY APPLICATIONS by Erin Rae Burnight A thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in Genetics in the Gradua...
متن کاملTargeting CD8 T-Cell Metabolism in Transplantation
Infiltration of effector CD8 T cells plays a major role in allograft rejection, and increases in memory and terminally differentiated effector memory CD8 T cells are associated with long-term allograft dysfunction. Alternatively, CD8 regulatory T cells suppress the inflammatory responses of effector lymphocytes and induce allograft tolerance in animal models. Recently, there has been a renewed ...
متن کاملTargeting Purinergic Receptors in Islet Transplantation
Transplanted islets are exposed to a distinctively hostile immunological environment. Grafted islets typically encounter a combination of innate, allogeneic and anti-islet immune responses—the relative contributions of which are not fully understood. The relatively low success rate of islet transplantation compared with other organs suggests that current immunomodulatory protocols are inadequat...
متن کاملBarriers and recent advances in non-viral vectors targeting the lungs for cystic fibrosis gene therapy
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in CFTR genes that affect chloride ion channel. The CF is a good nominee for gene therapy as the asymptomatic carriers are phenotypically normal, and the desired cells are accessible for vector delivery. Gene therapy shows promising effects involving the correction of gene or replacement of the mutant gene with the func...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Kidney International
سال: 1999
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.1999.00513.x