منابع مشابه
FUN-L: gene prioritization for RNAi screens
MOTIVATION Most biological processes remain only partially characterized with many components still to be identified. Given that a whole genome can usually not be tested in a functional assay, identifying the genes most likely to be of interest is of critical importance to avoid wasting resources. RESULTS Given a set of known functionally related genes and using a state-of-the-art approach to...
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The nematode worm Caenorhabditis elegans is a genetic model organism linked to an impressive portfolio of fundamental discoveries in biology. This free-living nematode, which can be easily and inexpensively grown in the laboratory, is also a natural vehicle for screening for drugs that are active against nematode parasites. Here, we show that chemistry-to-gene screens using this animal model ca...
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MOTIVATION Genome-wide RNA interference (RNAi) experiments are becoming a widely used approach for identifying intracellular molecular pathways of specific functions. However, detecting all relevant genes involved in a biological process is challenging, because typically only few samples per gene knock-down are available and readouts tend to be very noisy. We investigate the reliability of top ...
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Within a time frame of about ten years, experimental (interactive) media installations and performances have gained recognition as new art forms in public space. Artworks explore the interconnectedness of public space, interaction, and new media. Urban Screens investigates how the growing infrastructure of dynamic digital displays in urban space, currently dominated by commercial forces, can be...
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umail.umd.edu Over the past decade, phylogeography grew as a discipline because allelic phylogenies provided explicitly historical tools for the study of geographical subdivision among populations1.Analysing the relative ages and historical relationships of alleles in a geographical context could distinguish ongoing processes such as GENE FLOW (see Glossary) from previous events such as range e...
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ژورنال
عنوان ژورنال: Nature
سال: 2001
ISSN: 0028-0836,1476-4687
DOI: 10.1038/35083721