Gene replacement therapy provides benefit in an adult mouse model of Leigh syndrome
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چکیده
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cost benefits of rehabilitation after acute coronary syndrome in iran; using an epidemiological model
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Fatal breathing dysfunction in a mouse model of Leigh syndrome.
Leigh syndrome (LS) is a subacute necrotizing encephalomyelopathy with gliosis in several brain regions that usually results in infantile death. Loss of murine Ndufs4, which encodes NADH dehydrogenase (ubiquinone) iron-sulfur protein 4, results in compromised activity of mitochondrial complex I as well as progressive neurodegenerative and behavioral changes that resemble LS. Here, we report the...
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Gene therapy based on interleukin-12 loaded chitosan nanoparticles in a mouse model of fibrosarcoma
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Background: Gaucher disease is an autosomal recessive inherited lysosomal storage disorder that affects many of the body's organs and tissues by defective function of the catabolic enzyme β-glucocerebrosidase. Gene therapy is one of the efficient ways for treatment of this disease. Due to the lack of appropriate animal models, in the field of gene therapy little progress has been done.Mate...
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ژورنال
عنوان ژورنال: Brain
سال: 2020
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/awaa105