Gene Regulation: The Cohesin Ring Connects Developmental Highways
نویسندگان
چکیده
منابع مشابه
Gene Regulation: The Cohesin Ring Connects Developmental Highways
How does cohesin regulate gene expression and development independently of its roles in sister chromatid cohesion and chromosome segregation? Recent studies show that cohesin, through multiple mechanisms, directly controls transcription of genes that regulate morphogenesis, differentiation, cell proliferation and pluripotency.
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During cell division the cohesin complex mediates the pairing of sister chromatids. Emerging evidence shows that cohesin also has roles in interphase cells. New studies, including that of Gullerova and Proudfoot (2008) in this issue, reveal how cohesin is targeted to specific sites on chromosomes and implicate cohesin in the regulation of gene expression.
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Cohesin is a multisubunit protein complex that plays an integral role in sister chromatid cohesion, DNA repair, and meiosis. Of significance, both over- and underexpression of cohesin are associated with cancer. It is generally believed that cohesin dysregulation contributes to cancer by leading to aneuploidy or chromosome instability. For cancers with loss of cohesin function, this idea seems ...
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C ohesin is a conserved protein complex with a well documented role in providing stable but reversible connections between sister chromatids during both mitosis and meiosis. Cohesin consists of two long coiled-coil proteins (SMC1 and SMC3) and two non-SMC subunits (SCC1/Rad21 and SCC3/SA) that combine to form a ring-like structure. Establishment, maintenance, and timely removal of cohesin-media...
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The cohesin complex is essential for sister chromatid cohesion during mitosis. Its Smc1 and Smc3 subunits are rod-shaped molecules with globular ABC-like ATPases at one end and dimerization domains at the other connected by long coiled coils. Smc1 and Smc3 associate to form V-shaped heterodimers. Their ATPase heads are thought to be bridged by a third subunit, Scc1, creating a huge triangular r...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2010
ISSN: 0960-9822
DOI: 10.1016/j.cub.2010.09.036