Gene Network Biological Validity Based on Gene-Gene Interaction Relevance

Gene Network Biological Validity Based on Gene-Gene Interaction Relevance

In recent years, gene networks have become one of the most useful tools for modeling biological processes. Many inference gene network algorithms have been developed as techniques for extracting knowledge from gene expression data. Ensuring the reliability of the inferred gene relationships is a crucial task in any study in order to prove that the algorithms used are precise. Usually, this vali...

Biological Cluster Validity Indices Based on the Gene Ontology

With the invention of biotechnological high throughput methods like DNA microarrays and the analysis of the resulting huge amounts of biological data, clustering algorithms gain new popularity. In practice the question arises, which clustering algorithm as well as which parameter set generates the most promising results. Little work is addressed to the question of evaluating and comparing the c...

Title: Systematically Characterizing and Prioritizing Chemosensitivity Related Gene Based on Gene Ontology and Protein Interaction Network

Differentially Coexpressed Disease Gene Identification Based on Gene Coexpression Network

Screening disease-related genes by analyzing gene expression data has become a popular theme. Traditional disease-related gene selection methods always focus on identifying differentially expressed gene between case samples and a control group. These traditional methods may not fully consider the changes of interactions between genes at different cell states and the dynamic processes of gene ex...

Gene-Gene Interaction Study Between Genetic Polymorphisms of Folate Metabolism and MTR SNPs on Prognostic Features Impact for Breast Cancer

Background: Breast Cancer (BC), the second leading cause of cancer mortality after lung cancer and varied across the world due to genetic and environmental factors. In this study, we evaluated the interaction between the polymorphisms in genes encoding enzymes of folate metabolism: methylenetetrahydrofolate reductase (MTHFR), methionine synthesis reductase (MTR) with the BC prognostic factors. ...