Gene for sporadic Parkinson's disease: Common disease-common variants
نویسندگان
چکیده
منابع مشابه
Common Disease, Multiple Rare (and Distant) Variants
Genome-wide association (GWA) studies have emerged as a potentially powerful tool for discovery of new genes for common diseases, such as Alzheimer’s disease and stroke. But the common interpretation of GWA findings might be incorrect in many cases, according to a new study by Samuel Dickson, David Goldstein, and colleagues in this issue of PLoS Biology. Their results suggest that the signals i...
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OBJECTIVE Only a small fraction of coronary artery disease (CAD) heritability has been explained by common variants identified to date. Interactions between genes of importance to cardiovascular regulation may account for some of the missing heritability of CAD. This study aimed to investigate the role of gene-gene interactions in common variants in candidate cardiovascular genes in CAD. APPR...
متن کاملAggregating common, rare, and private variants in Alzheimer's disease genes
Chapter 1: Introduction Chapter 2: Background Chapter 3: Materials and Methods Chapter 4: Results Chapter 5: Conclusions References Appendix
متن کاملCommon NOTCH3 Variants and Cerebral Small-Vessel Disease
BACKGROUND AND PURPOSE The most common monogenic cause of cerebral small-vessel disease is cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, caused by NOTCH3 gene mutations. It has been hypothesized that more common variants in NOTCH3 may also contribute to the risk of sporadic small-vessel disease. Previously, 4 common variants (rs10404382, rs1043994, ...
متن کاملDisease risk prediction with rare and common variants
A number of studies have been conducted to investigate the predictive value of common genetic variants for complex diseases. To date, these studies have generally shown that common variants have no appreciable added predictive value over classical risk factors. New sequencing technology has enhanced the ability to identify rare variants that may have larger functional effects than common varian...
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ژورنال
عنوان ژورنال: Rinsho Shinkeigaku
سال: 2010
ISSN: 0009-918X,1882-0654
DOI: 10.5692/clinicalneurol.50.864