Gene expression profiling of progenitor cells isolated from rat rotator cuff musculotendinous junction
نویسندگان
چکیده
منابع مشابه
Rotator Cuff Tears at the Musculotendinous Junction: Classification and Surgical Options for Repair and Reconstruction
Although uncommon, rotator cuff tears that occur medially at the musculotendinous junction can result from acute trauma, anatomic force imbalance, or medial row cuff failure following a previous rotator cuff repair. The quality of the torn muscle and tendon along with the length of the remnant tendon stump should be considered before deciding on the most appropriate repair technique. When muscl...
متن کاملCharacterization of progenitor cells derived from torn human rotator cuff tendons by gene expression patterns of chondrogenesis, osteogenesis, and adipogenesis
BACKGROUND It is important to regenerate the tendon-to-bone interface after rotator cuff repair to prevent re-tears. The cells from torn human rotator cuff were targeted, and their capacity for multilineage differentiation was investigated. METHODS The edges of the rotator cuff were harvested during arthroscopic rotator cuff repair from nine patients, minced into pieces, and cultured on dishe...
متن کاملBiological Augmentation of Rotator Cuff Repair with Endothelial Progenitor Cells
Introduction: Acute and chronic rotator cuff tears represent a substantial clinical burden in our society and remain an unsolved problem in orthopaedics. Despite the evolution of minimally-invasive surgical techniques for rotator cuff repair, including mini-open and arthroscopic approaches, failure of surgically repaired rotator cuff tears to heal continues to represent a significant problem. E...
متن کاملGene expression analysis in calcific tendinopathy of the rotator cuff.
We evaluated the expression of several genes involved in tissue remodelling and bone development in patients with calcific tendinopathy of the rotator cuff. Biopsies from calcified and non-calcified areas were obtained from 10 patients (8 women and 2 men; average age: 55 years; range: 40-68) with calcific tendinopathy of the rotator cuff. To evaluate the expression of selected genes, RNA extrac...
متن کاملMuscle gene expression patterns in human rotator cuff pathology.
BACKGROUND Rotator cuff pathology is a common source of shoulder pain with variable etiology and pathoanatomical characteristics. Pathological processes of fatty infiltration, muscle atrophy, and fibrosis have all been invoked as causes for poor outcomes after rotator cuff tear repair. The aims of this study were to measure the expression of key genes associated with adipogenesis, myogenesis, a...
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ژورنال
عنوان ژورنال: BMC Musculoskeletal Disorders
سال: 2020
ISSN: 1471-2474
DOI: 10.1186/s12891-020-03190-9