GENE EXPRESSION MECHANISMS DURING HYPOXIA IN THE FETAL GUINEA PIG BRAIN.† 369
نویسندگان
چکیده
منابع مشابه
The fetal brain sparing response to hypoxia: physiological mechanisms.
How the fetus withstands an environment of reduced oxygenation during life in the womb has been a vibrant area of research since this field was introduced by Joseph Barcroft, a century ago. Studies spanning five decades have since used the chronically instrumented fetal sheep preparation to investigate the fetal compensatory responses to hypoxia. This defence is contingent on the fetal cardiova...
متن کاملChronic hypoxia increases the NO contribution of acetylcholine vasodilation of the fetal guinea pig heart.
To investigate the effect of chronic hypoxia (HPX) on vasodilation of the fetal heart, we exposed pregnant guinea pigs to room air or 12% O(2) for 4, 7, or 10 days. We excised hearts from anesthetized fetuses (60 +/- 3 days; 65-day gestation = term) and measured changes in both the coronary artery pressure of the isolated constant-flow preparation and endothelial nitric oxide synthase (eNOS) mR...
متن کاملChronic hypoxia impairs cytochrome oxidase activity via oxidative stress in selected fetal Guinea pig organs.
We hypothesized that chronic hypoxia disrupts mitochondrial function via oxidative stress in fetal organs. Pregnant guinea pig sows were exposed to either normoxia or hypoxia (10.5% O2, 14 days) in the presence or absence of the antioxidant, N-acetylcysteine (NAC). Near-term anesthetized fetuses were delivered via hysterotomy, and fetal livers, hearts, lungs, and forebrains harvested. We quanti...
متن کاملGlycogenesis in the liver of the fetal guinea pig.
In the developing fetal liver of many animals, the appearance of glycogen in quantities demonstrable by classical chemical methods is a relatively tardy and abrupt event. For example, using Sahyun and Alsberg’s (1) modification of Pfliiger’s technique, Hard et al. (2) have shown in the guinea pig that there is no detectable liver glycogen up to the 56th day of gestation (term 66 days) but that ...
متن کاملOntogeny of fetal movements in the guinea pig.
Assessment of fetal motility is an approach to evaluate the development and function of the nervous system before birth. Reference values for the time of first occurrence and the incidence of normal fetal movements are indispensable for studies in which prenatal motor activity is applied as a model to study the central and peripheral nervous systems. Studies on fetal motility have been performe...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1996
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199604001-00389