Gene expression in human ovarian tissue after xenografting
نویسندگان
چکیده
منابع مشابه
Gene expression in human ovarian tissue after xenografting.
Cryobanking and transplantation of ovarian tissue is a promising approach to restore fertility in cancer patients. However, ischemic stress following avascular ovarian cortex grafting is known to induce stromal tissue fibrosis and alterations in follicular development. The aim of the study was to analyze the impact of freeze-thawing and grafting procedures on gene expression in human ovarian ti...
متن کاملElectron paramagnetic resonance as a tool to evaluate human ovarian tissue reoxygenation after xenografting.
OBJECTIVE To develop electron paramagnetic resonance (EPR) oximetry as a tool to characterize the oxygen environment in human ovarian xenografts in the early postgrafting period. DESIGN Prospective experimental study. SETTING Gynecology research unit in a university hospital. PATIENT(S) Biopsies were obtained from 6 women aged 22-35 years. INTERVENTION(S) Frozen-thawed human ovarian tis...
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BACKGROUND Previous studies have demonstrated development of antral follicles in cryopreserved human ovarian tissue after autografting and xenografting, thus indicating successful preservation of follicular function. The study aim was to assess whether these follicles could also undergo periovulatory changes in response to hCG. METHODS Ovarian tissue from three patients were dehydrated in pro...
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Background: Reproductive toxicity studies (RTS) represent an important part of pre-clinical safety evaluation of any drug development process for human consumption. It is mandatory requirement that RTS must be completed before any drug can be administered to women of childbearing age. Therefore, at first segment of toxicity check the toxic effect of the drug on fertility must be tested on non-c...
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ژورنال
عنوان ژورنال: MHR: Basic science of reproductive medicine
سال: 2014
ISSN: 1460-2407,1360-9947
DOI: 10.1093/molehr/gau015