Gene expression cascades in pancreatic development

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Gene expression cascades in pancreatic development

The specialized endocrine and exocrine cells of the pancreas originally derive from a pool of apparently identical cells in the early gut endoderm. Serial changes in their gene expression program, controlled by a hierarchy of pancreatic transcription factors, direct this progression from multipotent progenitor cell to mature pancreatic cell. When the cells differentiate, this hierarchy of facto...

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ژورنال

عنوان ژورنال: Mechanisms of Development

سال: 2003

ISSN: 0925-4773

DOI: 10.1016/s0925-4773(02)00333-7