Gene Expression and Target Tissue Dose in the Rat Epidermis after Brief JP-8 and JP-8 Aromatic and Aliphatic Component Exposures
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چکیده
منابع مشابه
Effects of brief cutaneous JP-8 jet fuel exposures on time course of gene expression in the epidermis.
The jet fuel jet propulsion fuel 8 (JP-8) has been shown to cause an inflammatory response in the skin, which is characterized histologically by erythema, edema, and hyperplasia. Studies in laboratory animal skin and cultured keratinocytes have identified a variety of changes in protein levels related to inflammation, oxidative damage, apoptosis, and cellular growth. Most of these studies have ...
متن کاملDermal absorption and distribution of topically dosed jet fuels jet-A, JP-8, and JP-8(100).
Dermal exposure to jet fuels has received increased attention with the recent release of newer fuels with novel performance additives. The purpose of these studies was to assess the percutaneous absorption and cutaneous disposition of topically applied (25 microl/5 cm(2)) neat Jet-A, JP-8, and JP-8(100) jet fuels by monitoring the absorptive flux of the marker components 14C naphthalene and (3)...
متن کاملUrinary biomarkers of exposure to jet fuel (JP-8).
Benzene, naphthalene, and 1- and 2-naphthol were measured in urine samples obtained from 322 U.S. Air Force personnel categorized a priori as likely to have low, moderate, or high exposure to jet fuel [jet propulsion fuel-8 (JP-8)]. In postexposure samples, levels of these analytes in the high-exposure group were 3- to 29-fold greater than in the low-exposure group and 2- to 12-fold greater tha...
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The attractive aspects of fuels cells for replacement of batteries in lightweight applications are offset by the need to efficiently produce a hydrogen feed stream on demand. Hydrogen is itself impractical for storage and hydrocarbon fuels provide the highest density form of hydrogen storage when taking into account both weight and volume. Currently, traditional catalytic processes are used for...
متن کاملComputational and experimental study of JP-8, a surrogate, and its components in counterflow diffusion flames
Non-sooting counterflow diffusion flames have been studied both computationally and experimentally, using either JP-8, or a six-component JP-8 surrogate mixture, or its individual components. The computational study employs a counterflow diffusion flame model, the solution of which is coupled with arc length continuation to examine a wide variety of inlet conditions and to calculate extinction ...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2007
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfm037