Gene-environment interaction and Mendelian randomisation
نویسندگان
چکیده
منابع مشابه
Mendelian Randomisation: A Minireview
, © Wells This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and redistribution in any medium, provided that the original author and source are credited. Mendelian randomisation is a technique which, fuelled by the results of GWA studies, can be used to determine causal relationships between in...
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In The Lancet, Benjamin Voight and colleagues use mendelian randomisation analysis to invest igate the relation between HDL cholesterol and coronary heart disease. High HDL cholesterol concentration is associated with reduced risk of coronary heart disease in observational studies, but whether the association is causal cannot be unequivocally ascertained from these studies alone, and whether ra...
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To infer the causal association between childhood BMI and age at menarche, we performed a mendelian randomisation analysis using twelve established "BMI-increasing" genetic variants as an instrumental variable (IV) for higher BMI. In 8,156 women of European descent from the EPIC-Norfolk cohort, height was measured at age 39-77 years; age at menarche was self-recalled, as was body weight at age ...
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The notion of risk is central to epidemiological research, both in its original context of studying conditions thought to be caused by a particular factor and, more broadly, in predicting the probability of a condition for prognostic purposes. For prognostic research, all factors associated with the outcome are of interest, whether they are causal or not. In aetiological research, on the other ...
متن کاملEducation and coronary heart disease: mendelian randomisation study
Objective To determine whether educational attainment is a causal risk factor in the development of coronary heart disease.Design Mendelian randomisation study, using genetic data as proxies for education to minimise confounding.Setting The main analysis used genetic data from two large consortia (CARDIoGRAMplusC4D and SSGAC), comprising 112 studies from predominantly high income countries. Fin...
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ژورنال
عنوان ژورنال: Revue Neurologique
سال: 2019
ISSN: 0035-3787
DOI: 10.1016/j.neurol.2019.04.010