Gelatinization of pig bone insoluble collagen.

Isolation and characterization of a double chain intermolecular cross-linked peptide from insoluble calf bone collagen.

A double chain peptide containing the sodium borohydride-reduced intermolecular cross-link, hydroxylysinohydroxynorleucine, was isolated following sequential cyanogen bromide digestion and limited alkaline hydrolysis of insoluble calf bone collagen. Amino acid composition and NH2-terminal sequence analysis indicated that the peptide was highly acidic and consisted of 19 amino acid residues incl...

Modes of intermolecular cross-linking in mature insoluble collagen.

The structural unit of the collagen fibril is the tropocollagen molecule, a ropelike rodlet formed from three intertwined subunit strands of nearly equal molecular weight (I). Chromatographic analyses of denatured soluble collagens have indicated that the three subunit strands are all different, although two (designated al and a3) are very similar in composition (2). The third chain (012) is di...

Evaluation of Possible Beneficial Effect of Tricalcium Phosphate/Collagen (TCP/collagen) Nanocomposite Scaffold on Bone Healing in Rabbits: Biochemical Assessments

Objective- The aim of this study was to evaluate possible beneficial effect of tricalcium phosphate/collagen (TCP/collagene) nanocomposite scaffold on bone healing in rabbits using biochemical assessmentsDesign- Experimental studyAnimals- Twelve healthy male white New Zealand rabbitsProcedures- The rabbits wer...

Enzyme system in rat leucocyte granules which degrades insoluble collagen.

Scurvy results in decreased collagen synthesis and bone density in the guinea pig animal model.

The effect of severe ascorbic acid deficiency on bone remodeling and collagen synthesis was evaluated in a 21 day experiment, using the scorbutic guinea pig model. Animals (n = 6-7/group) were assigned to one of three groups: scorbutic, pair-fed ascorbic acid-replete, or ad libitum ascorbic acid-replete groups. After 2 weeks, scorbutic animals started voluntarily decreasing food intake and losi...