Gelatin microspheres crosslinked with genipin for local delivery of growth factors
نویسندگان
چکیده
منابع مشابه
Genipin crosslinked gelatin nanofibers for tissue engineering.
summary The objective of this study was to enhance the mechanical and thermo-mechanical properties of electrospun gelatin nanofibers, while maintaining their good bioactivity. In this work, genipin was used as crosslinker to achieve this goal. Electrospun gelatin nanofibers were crosslinked with genipin vapor at room temperature for 0 h, 6 h, 12 h, 24 h, 48 h and 72 h. The morphologies of the c...
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An effective paradigm for transplanting large numbers of neural stem cells after central nervous system (CNS) injury has yet to be established. Biomaterial scaffolds have shown promise in cell transplantation and in regenerative medicine, but improved scaffolds are needed. In this study we designed and optimized multifunctional and biocompatible chitosan-based films and microspheres for the del...
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In the long-term management of ulcerative colitis patients, repeat dosing maybe required. Since 5-ASA is largely absorbed from the upper intestine, selective delivery of drugs into the colon may be regarded as a better method of drug delivery with fewer side effects and a higher efficacy. The aim of this study was to prepare and evaluate a double coated multiparticulate system for 5-ASA deliver...
متن کاملGelatin Microspheres for the Controlled Release of All-trans-Retinoic Acid Topical Formulation and Drug Delivery Evaluation
A topical o/w cream containing tretinoin microspheres was prepared. Gelatin microspheres of tretinoin were prepared using coacervation method. These microspheres contained about 50% w/w tretinoin. The particle size range of microspheres was between 90-150 m m. In vitro drug release from microspheres and a cream formulation was studied. It was shown that drug release from microspheres followed H...
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ژورنال
عنوان ژورنال: Journal of Tissue Engineering and Regenerative Medicine
سال: 2010
ISSN: 1932-6254
DOI: 10.1002/term.267