Gating reaction mechanism of neuronal NMDA receptors
نویسندگان
چکیده
منابع مشابه
Gating reaction mechanism of neuronal NMDA receptors.
The activation mechanisms of recombinant N-methyl-d-aspartate receptors (NRs) have been established in sufficient detail to account for their single channel and macroscopic responses; however, the reaction mechanism of native NRs remains uncertain due to indetermination of the isoforms expressed and possible neuron-specific factors. To delineate the activation mechanism of native NRs, we examin...
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The NMDA receptor opens in response to binding of NMDA and glycine. However, it remains unclear where and how gating of the NMDA receptor pore is accomplished. We show that different point mutations between S645 and I655 (thus including the highly conserved SYTANLAAF motif) of M3c in NR2B lead to constitutively open channels. The current through these constitutively open channels are readily bl...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2012
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00551.2012